Agranulocytosis Following Dapsone Therapy

Dapsone agranulocytosis in a leprosy patient.

Dapsone-induced agranulocytosis is a rare adverse effect. There are various reports of agranulocytosis in patients treated with dapsone for malaria prophylaxis and other dermatological diseases. However, this adverse reaction in leprosy is not often encountered. We describe agranulocytosis in a young patient who was taking dapsone (100 mg) for borderline-tuberculoid leprosy in a rural environment.

Agranulocytosis and systemic candidiasis following clomipramine therapy.

References BRONSON, W.R., DE VITA, V.T., CARBONE, P.P. & COTLOVE, E. (1966) Pseudo-hyperkalemia due to release of potassium from white blood cells during clotting. New England Journal of Medicine, 274, No. 7; 369. CLAIN, A. (1973) (Ed.) Hamilton Bailey's Demonstrations of Physical Signs in Clinical Surgery. 15th Edn, p.333. John Wright & Son Ltd, Bristol. COORAY, G.H. (1952) Spontaneous rupture...

Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).

A case of agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone) is described. At the recommended dose of one tablet weekly this is apparently a rare occurrence but highlights one of the hazards in a changing climate of malarial prophylaxis in which the use of Maloprim is increasing.

Dapsone-induced agranulocytosis in patients with Hansen's disease*

How to cite this article: Contin LA, Rocha VB. Pseudo “fringe sign” in frontal fibrosing alopecia. An Bras Dermatol. 2017;92(6): 892-4. Dear Editor, Agranulocytosis induced by sulphonamide or dapsone (44-diaminodiphenylsulphone – DDS) is characterized by a low concentration or absence of granulocytes due to sulfone cytotoxicity effects on bone marrow and mononuclear cells.1 DDS is a structural ...

Nucleotide Therapy in Agranulocytosis.